After ten years of estrangement, twins Maggie and Milo coincidentally cheat death on the same day, prompting them to reunite and confront how their lives went so wrong. As the twins' reunion reinvigorates them both, they realize that the key to fixing their lives just may lie in fixing their relationship with each other.

Kristen Wiig stars as Imogene, a failed New York playwright awkwardly navigating the transition from Next Big Thing to Last Year's News. After both her career and relationship hit the skids, she's forced to make the humiliating move back home to New Jersey with her eccentric mother and younger brother (Annette Bening and Christopher Fitzgerald). Adding further insult to injury, there's a strange man sleeping in her old bedroom (Darren Criss) and an even stranger man sleeping in her mother's bed...